Evaluation of the Interaction between Long Telomeric DNA and Macrocyclic Hexaoxazole (6OTD) Dimer of a G-quadruplex Ligand

Evaluation of the Interaction between Long Telomeric DNA and Macrocyclic Hexaoxazole (6OTD) Dimer of a G-quadruplex Ligand

Macrocyclic hexaoxazole dimer of L2H2-6OTD-dimer (3) was newly synthesized as a telomeric G-quadruplex (G4) ligand, and interaction with long telomeric DNAs telo48, 72, and 96 was evaluated by means of electrophoresis mobility shift assay, CD spectra analysis, and CD melting experiments. The L2H2-6O...

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Bibliographic Details
Main Authors: Kazuo Nagasawa, Hiroyuki Seimiya, Takahiro Nakamura, Satoki Majima, Keisuke Iida
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:Molecules
Subjects:
macrocycles
G-quadruplex
telomestatin
telomere
oxazole
Online Access:http://www.mdpi.com/1420-3049/18/4/4328

Internet

http://www.mdpi.com/1420-3049/18/4/4328

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