3506 PRMT5 is a novel therapeutic target to enhance radiation therapy for cancer treatment

OBJECTIVES/SPECIFIC AIMS: Prostate cancer is the second leading cause of cancer-related death among men in the U.S. and over half of all prostate cancer patients receive radiation therapy (RT). RT induces double-strand breaks (DSBs) in DNA which are lethal to cells if not repaired. While potentially...

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Bibliographic Details
Main Authors: Jake L Owens, Elena Beketova, Samantha Tinsley, Andrew Asberry, Xuehong Deng, Chang-Deng Hu
Format: Article
Language:English
Published: Cambridge University Press 2019-03-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866119002577/type/journal_article