Novel aerosol treatment of airway hyper-reactivity and inflammation in a murine model of asthma with a soluble epoxide hydrolase inhibitor

Novel aerosol treatment of airway hyper-reactivity and inflammation in a murine model of asthma with a soluble epoxide hydrolase inhibitor

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Asthma currently affects more than 339 million people worldwide. In the present preliminary study, we examined the efficacy of a new, inhalable soluble epoxide hydrolase inhibitor (sEHI), 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), to attenuate airway inflammation, mucin secr...

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Bibliographic Details
Main Authors: Chuanzhen Zhang, Wei Li, Xiyuan Li, Debin Wan, Savannah Mack, Jingjing Zhang, Karen Wagner, Chang Wang, Bowen Tan, Jason Chen, Ching-Wen Wu, Kaori Tsuji, Minoru Takeuchi, Ziping Chen, Bruce D. Hammock, Kent E. Pinkerton, Jun Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020733/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020733/?tool=EBI

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