TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging.
Female reproductive cessation is one of the earliest age-related declines humans experience, occurring in mid-adulthood. Similarly, Caenorhabditis elegans' reproductive span is short relative to its total life span, with reproduction ceasing about a third into its 15-20 day adulthood. All of th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-12-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2791159?pdf=render |
| _version_ | 1811293829392760832 |
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| author | Shijing Luo Wendy M Shaw Jasmine Ashraf Coleen T Murphy |
| author_facet | Shijing Luo Wendy M Shaw Jasmine Ashraf Coleen T Murphy |
| author_sort | Shijing Luo |
| collection | DOAJ |
| description | Female reproductive cessation is one of the earliest age-related declines humans experience, occurring in mid-adulthood. Similarly, Caenorhabditis elegans' reproductive span is short relative to its total life span, with reproduction ceasing about a third into its 15-20 day adulthood. All of the known mutations and treatments that extend C. elegans' reproductive period also regulate longevity, suggesting that reproductive span is normally linked to life span. C. elegans has two canonical TGF-beta signaling pathways. We recently found that the TGF-beta Dauer pathway regulates longevity through the Insulin/IGF-1 Signaling (IIS) pathway; here we show that this pathway has a moderate effect on reproductive span. By contrast, TGF-beta Sma/Mab signaling mutants exhibit a substantially extended reproductive period, more than doubling reproductive span in some cases. Sma/Mab mutations extend reproductive span disproportionately to life span and act independently of known regulators of somatic aging, such as Insulin/IGF-1 Signaling and Dietary Restriction. This is the first discovery of a pathway that regulates reproductive span independently of longevity and the first identification of the TGF-beta Sma/Mab pathway as a regulator of reproductive aging. Our results suggest that longevity and reproductive span regulation can be uncoupled, although they appear to normally be linked through regulatory pathways. |
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| format | Article |
| id | doaj.art-8931e806e4f34783983a58a3d9990757 |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-04-13T05:08:24Z |
| publishDate | 2009-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-8931e806e4f34783983a58a3d99907572022-12-22T03:01:07ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042009-12-01512e100078910.1371/journal.pgen.1000789TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging.Shijing LuoWendy M ShawJasmine AshrafColeen T MurphyFemale reproductive cessation is one of the earliest age-related declines humans experience, occurring in mid-adulthood. Similarly, Caenorhabditis elegans' reproductive span is short relative to its total life span, with reproduction ceasing about a third into its 15-20 day adulthood. All of the known mutations and treatments that extend C. elegans' reproductive period also regulate longevity, suggesting that reproductive span is normally linked to life span. C. elegans has two canonical TGF-beta signaling pathways. We recently found that the TGF-beta Dauer pathway regulates longevity through the Insulin/IGF-1 Signaling (IIS) pathway; here we show that this pathway has a moderate effect on reproductive span. By contrast, TGF-beta Sma/Mab signaling mutants exhibit a substantially extended reproductive period, more than doubling reproductive span in some cases. Sma/Mab mutations extend reproductive span disproportionately to life span and act independently of known regulators of somatic aging, such as Insulin/IGF-1 Signaling and Dietary Restriction. This is the first discovery of a pathway that regulates reproductive span independently of longevity and the first identification of the TGF-beta Sma/Mab pathway as a regulator of reproductive aging. Our results suggest that longevity and reproductive span regulation can be uncoupled, although they appear to normally be linked through regulatory pathways.http://europepmc.org/articles/PMC2791159?pdf=render |
| spellingShingle | Shijing Luo Wendy M Shaw Jasmine Ashraf Coleen T Murphy TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. PLoS Genetics |
| title | TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. |
| title_full | TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. |
| title_fullStr | TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. |
| title_full_unstemmed | TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. |
| title_short | TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. |
| title_sort | tgf beta sma mab signaling mutations uncouple reproductive aging from somatic aging |
| url | http://europepmc.org/articles/PMC2791159?pdf=render |
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