Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage

Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage

Abstract Background Gouty arthritis is characterized by the deposition of monosodium urate (MSU) within synovial joints and tissues due to increased urate concentrations. In this study, we explored the effect of the natural compound curcumin on the MSU crystal-stimulated inflammatory response. Metho...

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Bibliographic Details
Main Authors: Baofeng Chen, Hongmei Li, Guochun Ou, Long Ren, Xiaohong Yang, Mei Zeng
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Arthritis Research & Therapy
Subjects:
Curcumin
NF-κB
IκBα
MSU
Gout
Online Access:http://link.springer.com/article/10.1186/s13075-019-1974-z

Internet

http://link.springer.com/article/10.1186/s13075-019-1974-z

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