Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels
Mutations that modulate the activity of ion channels are essential tools to understand the biophysical determinants that control their gating. Here authors reveal the role played by a single residue in the second transmembrane domain of vertebrate and invertebrate two-pore domain potassium channels.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-08710-3 |
| _version_ | 1818405275264090112 |
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| author | Ismail Ben Soussia Sonia El Mouridi Dawon Kang Alice Leclercq-Blondel Lamyaa Khoubza Philippe Tardy Nora Zariohi Marie Gendrel Florian Lesage Eun-Jin Kim Delphine Bichet Olga Andrini Thomas Boulin |
| author_facet | Ismail Ben Soussia Sonia El Mouridi Dawon Kang Alice Leclercq-Blondel Lamyaa Khoubza Philippe Tardy Nora Zariohi Marie Gendrel Florian Lesage Eun-Jin Kim Delphine Bichet Olga Andrini Thomas Boulin |
| author_sort | Ismail Ben Soussia |
| collection | DOAJ |
| description | Mutations that modulate the activity of ion channels are essential tools to understand the biophysical determinants that control their gating. Here authors reveal the role played by a single residue in the second transmembrane domain of vertebrate and invertebrate two-pore domain potassium channels. |
| first_indexed | 2024-12-14T08:53:27Z |
| format | Article |
| id | doaj.art-89358a70ca0b4f15867e6e9b7f65b48a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T08:53:27Z |
| publishDate | 2019-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-89358a70ca0b4f15867e6e9b7f65b48a2022-12-21T23:09:00ZengNature PortfolioNature Communications2041-17232019-02-0110111310.1038/s41467-019-08710-3Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channelsIsmail Ben Soussia0Sonia El Mouridi1Dawon Kang2Alice Leclercq-Blondel3Lamyaa Khoubza4Philippe Tardy5Nora Zariohi6Marie Gendrel7Florian Lesage8Eun-Jin Kim9Delphine Bichet10Olga Andrini11Thomas Boulin12Institut NeuroMyoGène, Univ Lyon, Université Claude Bernard Lyon 1Institut NeuroMyoGène, Univ Lyon, Université Claude Bernard Lyon 1Department of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National UniversityInstitut NeuroMyoGène, Univ Lyon, Université Claude Bernard Lyon 1Institut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, CNRS UMR 7275, Université de Nice Sophia AntipolisInstitut NeuroMyoGène, Univ Lyon, Université Claude Bernard Lyon 1Institut NeuroMyoGène, Univ Lyon, Université Claude Bernard Lyon 1Institut NeuroMyoGène, Univ Lyon, Université Claude Bernard Lyon 1Institut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, CNRS UMR 7275, Université de Nice Sophia AntipolisDepartment of Physiology, College of Medicine and Institute of Health Sciences, Gyeongsang National UniversityInstitut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, CNRS UMR 7275, Université de Nice Sophia AntipolisInstitut NeuroMyoGène, Univ Lyon, Université Claude Bernard Lyon 1Institut NeuroMyoGène, Univ Lyon, Université Claude Bernard Lyon 1Mutations that modulate the activity of ion channels are essential tools to understand the biophysical determinants that control their gating. Here authors reveal the role played by a single residue in the second transmembrane domain of vertebrate and invertebrate two-pore domain potassium channels.https://doi.org/10.1038/s41467-019-08710-3 |
| spellingShingle | Ismail Ben Soussia Sonia El Mouridi Dawon Kang Alice Leclercq-Blondel Lamyaa Khoubza Philippe Tardy Nora Zariohi Marie Gendrel Florian Lesage Eun-Jin Kim Delphine Bichet Olga Andrini Thomas Boulin Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels Nature Communications |
| title | Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels |
| title_full | Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels |
| title_fullStr | Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels |
| title_full_unstemmed | Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels |
| title_short | Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels |
| title_sort | mutation of a single residue promotes gating of vertebrate and invertebrate two pore domain potassium channels |
| url | https://doi.org/10.1038/s41467-019-08710-3 |
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