Determination and pharmacokinetics study of UK-5099 in mouse plasma by LC–MS/MS

Abstract Background UK-5099 is a potent mitochondrial acetone carrier inhibitor, that exhibits anticancer activity. Recently, the anti-Toxoplasma gondii activity of UK-5099 was proposed, and in vivo studies of its pharmacokinetics in BALB/c mice are necessary to further evaluate the clinical effect...

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Bibliographic Details
Main Authors: Qingyuan Zeng, Hongfei Si, Kun Lv, Jiao Mo, Xinnian Wang, Biqing Yan, Jili Zhang
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Veterinary Research
Subjects:
Online Access:https://doi.org/10.1186/s12917-022-03245-0