Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression

Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression

Posiphen tartrate (Posiphen) is an orally available small molecule that targets a conserved regulatory element in the mRNAs of amyloid precursor protein (APP) and α-synuclein (αSYN) and inhibits their translation. APP and αSYN can cause neurodegeneration when their aggregates induce neurotoxicity. T...

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Bibliographic Details
Main Authors: Xu-Qiao Chen, Carlos A. Barrero, Rodrigo Vasquez-Del Carpio, E. Premkumar Reddy, Chiara Fecchio, Salim Merali, Alessia Deglincerti, Cheng Fang, Jack Rogers, Maria L. Maccecchini
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
Posiphen
stable-isotope labeling by amino acids in cell culture
proteomics
huntingtin
iron response elements
iron regulatory protein 1
Online Access:https://www.mdpi.com/1999-4923/13/12/2109

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https://www.mdpi.com/1999-4923/13/12/2109

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