Pathological and Synaptic Morphological Changes of the Olfactory Bulb in APP/PS1 Model Mice at Different Ages and the Intervention Effect of Memantine

Pathological and Synaptic Morphological Changes of the Olfactory Bulb in APP/PS1 Model Mice at Different Ages and the Intervention Effect of Memantine

Objective To compare and explore the histopathological and ultrastructural characteristics of the olfactory bulb in 6- and 12-month-old APP/PS1 double-transgenic mice and their spatial learning and memory ability, as well as the effects of memantine intervention.Methods Three-month-old SPF male APP/...

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Bibliographic Details
Main Authors: LIU Jiani, LIU Jiangang, WEI Yun, LI Hao, LUO Zenggang, WANG Yi, LI Kun
Format: Article
Language:zho
Published: Editorial Office of Laboratory Animal and Comparative Medicine 2022-06-01
Series:Shiyan dongwu yu bijiao yixue
Subjects:
alzheimer's disease
app/ps1 transgenic mice
olfactory bulb
synapses
pathological morphology
Online Access:https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2022.001

Internet

https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2022.001

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