Ligand-Based Drug Design of Genipin Derivatives with Cytotoxic Activity against HeLa Cell Line: A Structural and Theoretical Study

Ligand-Based Drug Design of Genipin Derivatives with Cytotoxic Activity against HeLa Cell Line: A Structural and Theoretical Study

Cervical cancer is a malignant neoplastic disease, mainly associated to HPV infection, with high mortality rates. Among natural products, iridoids have shown different biological activities, including cytotoxic and antitumor effects, in different cancer cell types. Geniposide and its aglycone Genipi...

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Bibliographic Details
Main Authors: Diana López-López, Rodrigo Said Razo-Hernández, César Millán-Pacheco, Mario Alberto Leyva-Peralta, Omar Aristeo Peña-Morán, Jessica Nayelli Sánchez-Carranza, Verónica Rodríguez-López
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceuticals
Subjects:
cytotoxic iridoids
SAR
DFT
dipole moment
QSAR
ligand-based design
Online Access:https://www.mdpi.com/1424-8247/16/12/1647

Internet

https://www.mdpi.com/1424-8247/16/12/1647

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