Synthesis and evaluation of TSPO-targeting radioligand [18F]F-TFQC for PET neuroimaging in epileptic rats

Synthesis and evaluation of TSPO-targeting radioligand [18F]F-TFQC for PET neuroimaging in epileptic rats

The translocator protein (TSPO) positron emission tomography (PET) can noninvasively detect neuroinflammation associated with epileptogenesis and epilepsy. This study explored the role of the TSPO-targeting radioligand [18F]F-TFQC, an m-trifluoromethyl ER176 analog, in the PET neuroimaging of epilep...

Full description

Bibliographic Details
Main Authors: Wenhui Fu, Qingyu Lin, Zhequan Fu, Tingting Yang, Dai Shi, Pengcheng Ma, Hongxing Su, Yunze Wang, Guobing Liu, Jing Ding, Hongcheng Shi, Dengfeng Cheng
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Fluorine-18
TSPO
PET
Epilepsy
Neuroimaging
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524002272

Internet

http://www.sciencedirect.com/science/article/pii/S2211383524002272

Similar Items