Cryptopatches Are Essential for the Development of Human GALT
Abnormal gut-associated lymphoid tissue (GALT) in humans is associated with infectious and autoimmune diseases, which cause dysfunction of the gastrointestinal (GI) tract immune system. To aid in investigating GALT pathologies in vivo, we bioengineered a human-mouse chimeric model characterized by t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-06-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124713002702 |
| _version_ | 1818663988446101504 |
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| author | Tomonori Nochi Paul W. Denton Angela Wahl J. Victor Garcia |
| author_facet | Tomonori Nochi Paul W. Denton Angela Wahl J. Victor Garcia |
| author_sort | Tomonori Nochi |
| collection | DOAJ |
| description | Abnormal gut-associated lymphoid tissue (GALT) in humans is associated with infectious and autoimmune diseases, which cause dysfunction of the gastrointestinal (GI) tract immune system. To aid in investigating GALT pathologies in vivo, we bioengineered a human-mouse chimeric model characterized by the development of human GALT structures originating in mouse cryptopatches. This observation expands our mechanistic understanding of the role of cryptopatches in human GALT genesis and emphasizes the evolutionary conservation of this developmental process. Immunoglobulin class switching to IgA occurs in these GALT structures, leading to numerous human IgA-producing plasma cells throughout the intestinal lamina propria. CD4+ T cell depletion within GALT structures results from HIV infection, as it does in humans. This human-mouse chimeric model represents the most comprehensive experimental platform currently available for the study and for the preclinical testing of therapeutics designed to repair disease-damaged GALT. |
| first_indexed | 2024-12-17T05:25:35Z |
| format | Article |
| id | doaj.art-894b5b83df21406c9877cd40e0dae455 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-17T05:25:35Z |
| publishDate | 2013-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-894b5b83df21406c9877cd40e0dae4552022-12-21T22:01:53ZengElsevierCell Reports2211-12472013-06-01361874188410.1016/j.celrep.2013.05.037Cryptopatches Are Essential for the Development of Human GALTTomonori Nochi0Paul W. Denton1Angela Wahl2J. Victor Garcia3Division of Infectious Diseases, Center for AIDS Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USADivision of Infectious Diseases, Center for AIDS Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USADivision of Infectious Diseases, Center for AIDS Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USADivision of Infectious Diseases, Center for AIDS Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USAAbnormal gut-associated lymphoid tissue (GALT) in humans is associated with infectious and autoimmune diseases, which cause dysfunction of the gastrointestinal (GI) tract immune system. To aid in investigating GALT pathologies in vivo, we bioengineered a human-mouse chimeric model characterized by the development of human GALT structures originating in mouse cryptopatches. This observation expands our mechanistic understanding of the role of cryptopatches in human GALT genesis and emphasizes the evolutionary conservation of this developmental process. Immunoglobulin class switching to IgA occurs in these GALT structures, leading to numerous human IgA-producing plasma cells throughout the intestinal lamina propria. CD4+ T cell depletion within GALT structures results from HIV infection, as it does in humans. This human-mouse chimeric model represents the most comprehensive experimental platform currently available for the study and for the preclinical testing of therapeutics designed to repair disease-damaged GALT.http://www.sciencedirect.com/science/article/pii/S2211124713002702 |
| spellingShingle | Tomonori Nochi Paul W. Denton Angela Wahl J. Victor Garcia Cryptopatches Are Essential for the Development of Human GALT Cell Reports |
| title | Cryptopatches Are Essential for the Development of Human GALT |
| title_full | Cryptopatches Are Essential for the Development of Human GALT |
| title_fullStr | Cryptopatches Are Essential for the Development of Human GALT |
| title_full_unstemmed | Cryptopatches Are Essential for the Development of Human GALT |
| title_short | Cryptopatches Are Essential for the Development of Human GALT |
| title_sort | cryptopatches are essential for the development of human galt |
| url | http://www.sciencedirect.com/science/article/pii/S2211124713002702 |
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