Histone deacetylase inhibitors mitigate antipsychotic risperidone-induced motor side effects in aged mice and in a mouse model of Alzheimer’s disease

Histone deacetylase inhibitors mitigate antipsychotic risperidone-induced motor side effects in aged mice and in a mouse model of Alzheimer’s disease

Antipsychotic drugs are still widely prescribed to control various severe neuropsychiatric symptoms in the elderly and dementia patients although they are off-label use in the United States. However, clinical practice shows greater side effects and lower efficacy of antipsychotics for this vulnerabl...

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Bibliographic Details
Main Authors: Guadalupe Rodriguez, Daniel W. Fisher, Bryan McClarty, Janitza Montalvo-Ortiz, Qiaoling Cui, C. Savio Chan, Hongxin Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Psychiatry
Subjects:
antipsychotics
HDAC inhibitors
risperidone
neuropsychiatric symptoms
epigenetic
motor side effects
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1020831/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1020831/full

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