Correlation Patterns Among B7 Family Ligands and Tryptophan Degrading Enzymes in Hepatocellular Carcinoma

Correlation Patterns Among B7 Family Ligands and Tryptophan Degrading Enzymes in Hepatocellular Carcinoma

Mechanisms of dysfunctional T cell immunity in Hepatocellular Carcinoma (HCC) need to be well defined. B7 family molecules provide both co-stimulatory and co-inhibitory signals to T cells while tryptophan degrading enzymes like Indoleamine 2,3 dioxygenase (IDO) and Tryptophan 2,3 Dioxygenase (TDO) m...

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Bibliographic Details
Main Authors: Raghavan Chinnadurai, Rafaela Scandolara, Olatunji B. Alese, Dalia Arafat, Deepak Ravindranathan, Alton B. Farris, Bassel F. El-Rayes, Greg Gibson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
B7 family molecules
indoleamine 2,3 dioxygenase
hepatocellular carcinoma
T cell immunity
co-stimulation
co-inhibition
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01632/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01632/full

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