Targeting TREM2 on tumor-associated macrophages enhances immunotherapy

Targeting TREM2 on tumor-associated macrophages enhances immunotherapy

Summary: Converting checkpoint inhibitor (CPI)-resistant individuals to being responsive requires identifying suppressive mechanisms. We identify TREM2+ tumor-associated macrophages (TAMs) as being correlated with exhausted CD8+ tumor-infiltrating lymphocytes (TILs) in mouse syngeneic tumor models a...

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Bibliographic Details
Main Authors: Mikhail Binnewies, Joshua L. Pollack, Joshua Rudolph, Subhadra Dash, Marwan Abushawish, Tian Lee, Nadine S. Jahchan, Pamela Canaday, Erick Lu, Manith Norng, Shilpa Mankikar, Victoria M. Liu, Xiaoyan Du, Amanda Chen, Ranna Mehta, Rachael Palmer, Vladislava Juric, Linda Liang, Kevin P. Baker, Leonard Reyno, Matthew F. Krummel, Michel Streuli, Venkataraman Sriram
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
tumor-associated macrophages
immunotherapy
immunosuppression
TAM
TREM2
microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721013085

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http://www.sciencedirect.com/science/article/pii/S2211124721013085

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