Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

Drugs useful in prevention/treatment of obesity could improve health. Cholecystokinin (CCK) is a key regulator of appetite, working through the type 1 CCK receptor (CCK1R); however, full agonists have not stimulated more weight loss than dieting. We proposed an alternate strategy to target this rece...

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Bibliographic Details
Main Authors: Kaleeckal G. Harikumar, Thomas Coudrat, Aditya J. Desai, Maoqing Dong, Daniela G. Dengler, Sebastian G. B. Furness, Arthur Christopoulos, Denise Wootten, Eduard A. Sergienko, Patrick M. Sexton, Laurence J. Miller
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Endocrinology
Subjects:
cholecystokinin
cholecystokinin receptor
allosteric modulation
cholesterol
obesity
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.789957/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.789957/full

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