Impaired SNF2L Chromatin Remodeling Prolongs Accessibility at Promoters Enriched for Fos/Jun Binding Sites and Delays Granule Neuron Differentiation

Impaired SNF2L Chromatin Remodeling Prolongs Accessibility at Promoters Enriched for Fos/Jun Binding Sites and Delays Granule Neuron Differentiation

Chromatin remodeling proteins utilize the energy from ATP hydrolysis to mobilize nucleosomes often creating accessibility for transcription factors within gene regulatory elements. Aberrant chromatin remodeling has diverse effects on neuroprogenitor homeostasis altering progenitor competence, prolif...

Full description

Bibliographic Details
Main Authors: Laura R. Goodwin, Gerardo Zapata, Sara Timpano, Jacob Marenger, David J. Picketts
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
SMARCA1
Snf2L
ISWI chromatin remodeler
cerebellar granule neuron progenitors
ATAC-seq
chromatin accessibility
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.680280/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.680280/full

Similar Items