Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation

Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation

IntroductionCytomegalovirus (CMV) viremia remains a major contributor to clinical complications in solid organ transplant (SOT) patients, including organ injury, morbidity and mortality. Given their critical role in antiviral defense, CD8+ T cells are essential for protective immunity against CMV.Me...

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Bibliographic Details
Main Authors: Yumeng Sun, Subha Sen, Rajesh Parmar, Janice Arakawa-Hoyt, Monica Cappelletti, Maura Rossetti, David W. Gjertson, Tara K. Sigdel, Minnie M. Sarwal, Joanna M. Schaenman, Suphamai Bunnapradist, Lewis L. Lanier, Harry Pickering, Elaine F. Reed
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
kidney transplantation
cytomegalovirus (CMV)
single-cell RNA sequencing (sc-RNA seq)
CD8+ T cells
effector T cell differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1542531/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1542531/full

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