Insulin Sensitivity Controls Activity of Pathogenic CD4+ T Cells in Rheumatoid Arthritis

Insulin Sensitivity Controls Activity of Pathogenic CD4+ T Cells in Rheumatoid Arthritis

Hyperinsulinemia connects obesity, and a poor lipid profile, with type 2 diabetes (T2D). Here, we investigated consequences of insulin exposure for T cell function in the canonical autoimmunity of rheumatoid arthritis (RA). We observed that insulin levels correlated with the glycolytic index of CD4+...

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Bibliographic Details
Main Authors: Malin C. Erlandsson, Eric Malmhäll-Bah, Venkataragavan Chandrasekaran, Karin M. E. Andersson, Lisa M. Nilsson, Sofia Töyrä Silfverswärd, Rille Pullerits, Maria I. Bokarewa
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
insulin
CD4+ cells
senescence
arthritis
interferon
Online Access:https://www.mdpi.com/2073-4409/13/24/2124

Internet

https://www.mdpi.com/2073-4409/13/24/2124

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