Enhanced myocardial blood flow in ischemic cardiomyopathy by a slow-release synthetic prostacyclin agonist combined with coronary artery bypass grafting: The first human study in a Phase I/IIa clinical trial

Enhanced myocardial blood flow in ischemic cardiomyopathy by a slow-release synthetic prostacyclin agonist combined with coronary artery bypass grafting: The first human study in a Phase I/IIa clinical trial

BackgroundYS-1402, which is a polymerized form of the synthetic prostacyclin agonist ONO-1301, has been proven in several preclinical studies to induce therapeutic effects for patients with ischemic cardiomyopathy (ICM). In this human study, we assessed the safety, tolerability, and efficacy of YS-1...

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Bibliographic Details
Main Authors: Takuji Kawamura, Daisuke Yoshioka, Masashi Kawamura, Ryohei Matsuura, Ai Kawamura, Yusuke Misumi, Tsubasa Mikami, Yoshiki Sawa, Shigeru Miyagawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
ischemic cardiomyopathy
coronary artery bypass grafting
myocardial blood flow
functional recovery
first in human (FIH) trials
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1047666/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2023.1047666/full

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