Enhanced myocardial blood flow in ischemic cardiomyopathy by a slow-release synthetic prostacyclin agonist combined with coronary artery bypass grafting: The first human study in a Phase I/IIa clinical trial

Enhanced myocardial blood flow in ischemic cardiomyopathy by a slow-release synthetic prostacyclin agonist combined with coronary artery bypass grafting: The first human study in a Phase I/IIa clinical trial

BackgroundYS-1402, which is a polymerized form of the synthetic prostacyclin agonist ONO-1301, has been proven in several preclinical studies to induce therapeutic effects for patients with ischemic cardiomyopathy (ICM). In this human study, we assessed the safety, tolerability, and efficacy of YS-1...

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Bibliographic Details
Main Authors:	Takuji Kawamura, Daisuke Yoshioka, Masashi Kawamura, Ryohei Matsuura, Ai Kawamura, Yusuke Misumi, Tsubasa Mikami, Yoshiki Sawa, Shigeru Miyagawa
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	ischemic cardiomyopathy coronary artery bypass grafting myocardial blood flow functional recovery first in human (FIH) trials
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2023.1047666/full

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