Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells

Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells

DNA damage response inhibitors (DDRi) may selectively enhance the inactivation of tumor cells in combination with ionizing radiation (IR). The induction of senescence may be the key mechanism of tumor cell inactivation in this combinatorial treatment. In the current study the effect of combined IR w...

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Váldodahkkit: Clara Dobler, Tina Jost, Markus Hecht, Rainer Fietkau, Luitpold Distel
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: MDPI AG 2020-09-01
Ráidu:Cells
Fáttát:
HNSCC
DNA damage response inhibitor
kinase inhibitor
senescence
ATM
ATR
Liŋkkat:https://www.mdpi.com/2073-4409/9/9/2012

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https://www.mdpi.com/2073-4409/9/9/2012

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