Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells

Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells

DNA damage response inhibitors (DDRi) may selectively enhance the inactivation of tumor cells in combination with ionizing radiation (IR). The induction of senescence may be the key mechanism of tumor cell inactivation in this combinatorial treatment. In the current study the effect of combined IR w...

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Bibliographic Details
Main Authors: Clara Dobler, Tina Jost, Markus Hecht, Rainer Fietkau, Luitpold Distel
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
HNSCC
DNA damage response inhibitor
kinase inhibitor
senescence
ATM
ATR
Online Access:https://www.mdpi.com/2073-4409/9/9/2012

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