Mesenchymal stem cells reversibly de-differentiate myofibroblasts to fibroblast-like cells by inhibiting the TGF-β-SMAD2/3 pathway

Mesenchymal stem cells reversibly de-differentiate myofibroblasts to fibroblast-like cells by inhibiting the TGF-β-SMAD2/3 pathway

Abstract Background Myofibroblasts (MFB), one of the major effectors of pathologic fibrosis, mainly derived from the activation of fibroblast to myofibroblast transition (FMT). Although MFBs were historically considered terminally differentiated cells, their potential for de-differentiation was rece...

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Príomhchruthaitheoirí: Ruohao Xu, Miao Wu, Yawen Wang, Chao Li, Lingji Zeng, Yulian Wang, Maozhi Xiao, Xiaomei Chen, Suxia Geng, Peilong Lai, Xin Du, Jianyu Weng
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: BMC 2023-04-01
Sraith:Molecular Medicine
Ábhair:
Mesenchymal stem cell
Fibroblast
Myofibroblast
TGF-β1
De-differentiation
Rochtain ar líne:https://doi.org/10.1186/s10020-023-00630-9

Ar líne

https://doi.org/10.1186/s10020-023-00630-9

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