The Legionella pneumophila effector DenR hijacks the host NRas proto-oncoprotein to downregulate MAPK signaling

The Legionella pneumophila effector DenR hijacks the host NRas proto-oncoprotein to downregulate MAPK signaling

Summary: Small GTPases of the Ras subfamily are best known for their role as proto-oncoproteins, while their function during microbial infection has remained elusive. Here, we show that Legionella pneumophila hijacks the small GTPase NRas to the Legionella-containing vacuole (LCV) surface. A CRISPR...

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Bibliographic Details
Main Authors: Stephanie S. Lehman, Chad D. Williamson, Trisha Tucholski, Nicole A. Ellis, Sabrina Bouchard, Michal Jarnik, Morgan Allen, Aleksandra Nita-Lazar, Matthias P. Machner
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Cell Reports
Subjects:
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724003619

Internet

http://www.sciencedirect.com/science/article/pii/S2211124724003619

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