On variational solutions for whole brain serial-section histology using a Sobolev prior in the computational anatomy random orbit model.

This paper presents a variational framework for dense diffeomorphic atlas-mapping onto high-throughput histology stacks at the 20 μm meso-scale. The observed sections are modelled as Gaussian random fields conditioned on a sequence of unknown section by section rigid motions and unknown diffeomorphi...

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Bibliographic Details
Main Authors: Brian C Lee, Daniel J Tward, Partha P Mitra, Michael I Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-12-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1006610