Functional insights from a surface antigen mRNA-bound proteome

Functional insights from a surface antigen mRNA-bound proteome

Trypanosoma brucei is the causative agent of human sleeping sickness. The parasites’ variant surface glycoprotein (VSG) enables them to evade adaptive immunity via antigenic variation. VSG comprises 10% of total cell protein and the high stability of VSG mRNA is essential for trypanosome survival. T...

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Bibliographic Details
Main Authors: Larissa Melo do Nascimento, Franziska Egler, Katharina Arnold, Nina Papavasiliou, Christine Clayton, Esteban Erben
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
RNA-binding proteins
VSG
Trypanosoma brucei
CFB2
antigenic variation
F-box
Online Access:https://elifesciences.org/articles/68136

Internet

https://elifesciences.org/articles/68136

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