Linked read sequencing resolves complex genomic rearrangements in gastric cancer metastases

Linked read sequencing resolves complex genomic rearrangements in gastric cancer metastases

Abstract Background Genome rearrangements are critical oncogenic driver events in many malignancies. However, the identification and resolution of the structure of cancer genomic rearrangements remain challenging even with whole genome sequencing. Methods To identify oncogenic genomic rearrangements...

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Bibliographic Details
Main Authors: Stephanie U. Greer, Lincoln D. Nadauld, Billy T. Lau, Jiamin Chen, Christina Wood-Bouwens, James M. Ford, Calvin J. Kuo, Hanlee P. Ji
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Genome Medicine
Subjects:
Whole genome analysis
Cancer rearrangements
High molecular weight DNA
Cancer drivers
Barcode linked sequence reads
Online Access:http://link.springer.com/article/10.1186/s13073-017-0447-8

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http://link.springer.com/article/10.1186/s13073-017-0447-8

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