Design of Novel Coumarin Derivatives as NUDT5 Antagonists That Act by Restricting ATP Synthesis in Breast Cancer Cells

Design of Novel Coumarin Derivatives as NUDT5 Antagonists That Act by Restricting ATP Synthesis in Breast Cancer Cells

Breast cancer, a heterogeneous disease, is among the most frequently diagnosed diseases and is the second leading cause of death due to cancer among women after lung cancer. Phytoactives (plant-based derivatives) and their derivatives are safer than synthetic compounds in combating chemoresistance....

Full description

Bibliographic Details
Main Authors: Vidya Niranjan, Sanjana Jayaprasad, Akshay Uttarkar, Raviraj Kusanur, Jitendra Kumar
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
NUDT5
ATP synthesis
coumarin derivative
molecular dynamics simulation
metadynamics simulation
MTT assay
Online Access:https://www.mdpi.com/1420-3049/28/1/89

Internet

https://www.mdpi.com/1420-3049/28/1/89

Similar Items