Optimizing extrusion processes and understanding conformational changes in itraconazole amorphous solid dispersions using in-line UV–Vis spectroscopy and QbD principles

Optimizing extrusion processes and understanding conformational changes in itraconazole amorphous solid dispersions using in-line UV–Vis spectroscopy and QbD principles

This paper presents a comprehensive investigation of the manufacturing of itraconazole (ITZ) amorphous solid dispersions (ASDs) with Kolllidon® VA64 (KVA64) using hot-melt extrusion (HME) and in-line process monitoring, employing a Quality by Design (QbD) approach. A sequential Design of Experiments...

Full description

Bibliographic Details
Main Authors: Hetvi Triboandas, Mariana Bezerra, Juan Almeida, Matheus de Castro, Bianca Aloise Maneira Corrêa Santos, Walkiria Schlindwein
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Amorphous Solid Dispersion (ASD)
Hot-Melt Extrusion (HME)
Itraconazole (ITZ)
Quality by Design (QbD), In-line UV–Vis spectroscopy
Density Functional Theory (DFT)
Design of Experiments (DoE)
Online Access:http://www.sciencedirect.com/science/article/pii/S259015672400080X

Internet

http://www.sciencedirect.com/science/article/pii/S259015672400080X

Similar Items