Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals

<p>Abstract</p> <p>Background</p> <p>The laboratory rat <it>(Rattus norvegicus) </it>is one of the preferred model organisms in physiological and pharmacological research, although the availability of specific genetic models, especially gene knockouts, is li...

Full description

Bibliographic Details
Main Authors: van Roekel Henk S, Verheul Mark, Toonen Pim W, van Boxtel Ruben, Nijman Isaac J, Guryev Victor, Cuppen Edwin
Format: Article
Language:English
Published: BMC 2008-10-01
Series:BMC Genomics
Online Access:http://www.biomedcentral.com/1471-2164/9/460