Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals

Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals

<p>Abstract</p> <p>Background</p> <p>The laboratory rat <it>(Rattus norvegicus) </it>is one of the preferred model organisms in physiological and pharmacological research, although the availability of specific genetic models, especially gene knockouts, is li...

Full description

Bibliographic Details
Main Authors:	van Roekel Henk S, Verheul Mark, Toonen Pim W, van Boxtel Ruben, Nijman Isaac J, Guryev Victor, Cuppen Edwin
Format:	Article
Language:	English
Published:	BMC 2008-10-01
Series:	BMC Genomics
Online Access:	http://www.biomedcentral.com/1471-2164/9/460

Similar Items

Identification of genetic modifiers of behavioral phenotypes in serotonin transporter knockout rats
by: Nijman Isaäc J, et al.
Published: (2010-05-01)

Unexplained mismatch repair deficiency: Case closed
by: Ellis L. Eikenboom, et al.
Published: (2023-01-01)

Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells
by: Freek Manders, et al.
Published: (2022-12-01)

Constitutional mismatch repair-deficiency syndrome
by: Katharina Wimmer, et al.
Published: (2010-05-01)

Mismatch Repair Deficiency and Microsatellite Instability
by: Sandra Schöniger, et al.
Published: (2022-08-01)

Biallelic Mismatch Repair Deficiency in an Adolescent Female
by: Amber Hildreth, et al.
Published: (2018-01-01)

Mismatch repair deficiency in bilateral breast cancer
by: Milena Massumi Kozonoe, et al.
Published: (2024-08-01)

Practical guidance for mismatch repair-deficiency testing in endometrial cancer
by: Stelloo, E, et al.
Published: (2016)

Constitutional mismatch repair deficiency mimicking Lynch syndrome is associated with hypomorphic mismatch repair gene variants
by: Richard Gallon, et al.
Published: (2024-05-01)

Vaccines for immunoprevention of DNA mismatch repair deficient cancers
by: Steven Lipkin, et al.
Published: (2022-06-01)

Low frequency of mismatch repair deficiency in gallbladder cancer
by: Benjamin Goeppert, et al.
Published: (2019-05-01)

Haplotype block structure is conserved across mammals.
by: Victor Guryev, et al.
Published: (2006-07-01)

Efficacy, safety and biomarker analysis of durvalumab in patients with mismatch-repair deficient or microsatellite instability-high solid tumours
by: Birgit S. Geurts, et al.
Published: (2023-03-01)

DNA repair and mutagenesis /
by: Friedberg, Errol C.
Published: (2006)

Cerebral developmental venous anomalies in children with mismatch repair deficiency
by: Buket Kara, et al.
Published: (2022-12-01)

The efficiency of neoadjuvant chemotherapy in colon cancer with mismatch repair deficiency
by: Wu Yunlong, et al.
Published: (2023-02-01)

Mismatch repair protein deficiency in triple-negative breast carcinomas
by: Bayan Maraqa, et al.
Published: (2024-06-01)

Immune escape and resistance to immunotherapy in mismatch repair deficient tumors
by: Guillaume Mestrallet, et al.
Published: (2023-07-01)

DNA mismatch repair deficient (dMMR) endometrial cancer
by: Chia-Hao Liu, et al.
Published: (2022-09-01)

Genotype directed therapy in murine mismatch repair deficient tumors.
by: Melanie H Kucherlapati, et al.
Published: (2013-01-01)

Characterization of shared neoantigens landscape in Mismatch Repair Deficient Endometrial Cancer
by: Elisa De Paolis, et al.
Published: (2024-12-01)

Uncovering the role of mismatch repair deficiency and microsatellite instability in urothelial carcinoma
by: Filippo Pietrantonio, et al.
Published: (2024-07-01)

Somatic CpG hypermutation is associated with mismatch repair deficiency in cancer
by: Aidan Flynn, et al.
Published: (2024-07-01)

Microsatellite instability and mismatch repair protein deficiency: equal predictive markers?
by: Maja L. Nádorvári, et al.
Published: (2024-04-01)

Assessment of Immune Status in Patients with Mismatch Repair Deficiency Endometrial Cancer
by: Ma J, et al.
Published: (2024-04-01)

Mismatch repair deficiency testing in Lynch syndrome-associated urothelial tumors
by: Maria Rasmussen, et al.
Published: (2023-04-01)

Controversies and management of deficient mismatch repair gastrointestinal cancers in the neoadjuvant setting
by: Mélina Boutin, et al.
Published: (2023-03-01)

Mismatch repair deficient hematopoietic stem cells are preleukemic stem cells.
by: Yulan Qing, et al.
Published: (2017-01-01)

Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs
by: Sakuya Inanaga, et al.
Published: (2022-09-01)

Quantitative and Qualitative Proteome Characteristics Extracted from In-Depth Integrated Genomics and Proteomics Analysis
by: Teck Yew Low, et al.
Published: (2013-12-01)

Neoadjuvant immune checkpoint blockade in women with mismatch repair deficient endometrial cancer: a phase I study
by: Anneke L. Eerkens, et al.
Published: (2024-09-01)

This is not Lynch syndrome: lessons from misattributed diagnoses in constitutional mismatch repair deficiency
by: A.H. Mohammad, et al.
Published: (2024-12-01)

Distinct Clinical Characteristics and Predictors of Sporadic Mismatch Repair-Deficient Colorectal Cancer
by: Dan Li, et al.
Published: (2025-01-01)

Demystifying the Mystery of Genes: A Case Report on Constitutional Mismatch Repair Deficiency
by: Jose Siju, et al.
Published: (2024-07-01)

Deficient mismatch repair/microsatellite unstable colorectal cancer: therapeutic advances and questions
by: Baptiste Cervantes, et al.
Published: (2024-01-01)

73 Quantifying the effect of microsatellite instability and mismatch repair deficiency on the tumor microenvironment
by: William Qian, et al.
Published: (2023-11-01)

Organoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer
by: Yurong Song, et al.
Published: (2023-09-01)

DEEP MULTI-INSTANCE LEARNING FOR PREDICTING MISMATCH REPAIR DEFICIENCY IN COLON BIOPSIES
by: Sasa Andjelkovic, et al.
Published: (2022-01-01)

New Phenotypes of Potato Co-induced by Mismatch Repair Deficiency and Somatic Hybridization
by: Elena Rakosy-Tican, et al.
Published: (2019-01-01)

Mismatch repair and treatment resistance in ovarian cancer
by: van der Burg Maria EL, et al.
Published: (2006-07-01)