Human umbilical cord mesenchymal stem cell conditioned medium attenuates renal fibrosis by reducing inflammation and epithelial-to-mesenchymal transition via the TLR4/NF-κB signaling pathway in vivo and in vitro

Human umbilical cord mesenchymal stem cell conditioned medium attenuates renal fibrosis by reducing inflammation and epithelial-to-mesenchymal transition via the TLR4/NF-κB signaling pathway in vivo and in vitro

Abstract Background Renal fibrosis is characterized by infiltration of interstitial inflammatory cells and release of inflammatory mediators, activation and proliferation of fibroblasts, and deposition of excessive extracellular matrix (ECM). The aim of this study was to evaluate the effect of human...

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Bibliographic Details
Main Authors: Bo Liu, Fengxia Ding, Dong Hu, Yu Zhou, Chunlan Long, Lianju Shen, Yuanyuan Zhang, Deying Zhang, Guanghui Wei
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cell
Conditioned medium
Tubulointerstitial inflammation
Fibrosis
Online Access:http://link.springer.com/article/10.1186/s13287-017-0760-6

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http://link.springer.com/article/10.1186/s13287-017-0760-6

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