High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer

High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer

Abstract Background Protein tyrosine phosphatase non-receptor 12 (PTPN12) is ubiquitously tyrosine phosphatase with tumor suppressive properties. Methods PTPN12 expression was analyzed by immunohistochemistry on a tissue microarray with 13,660 clinical prostate cancer specimens. Results PTPN12 stain...

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Bibliographic Details
Main Authors: Sören A. Weidemann, Charlotte Sauer, Andreas M. Luebke, Christina Möller-Koop, Stefan Steurer, Claudia Hube-Magg, Franziska Büscheck, Doris Höflmayer, Maria Christina Tsourlakis, Till S. Clauditz, Ronald Simon, Guido Sauter, Cosima Göbel, Patrick Lebok, David Dum, Christoph Fraune, Simon Kind, Sarah Minner, Jakob Izbicki, Thorsten Schlomm, Hartwig Huland, Hans Heinzer, Eike Burandt, Alexander Haese, Markus Graefen, Asmus Heumann
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Cancer
Subjects:
PTPN12
Prostate cancer
Prognosis
Immunohistochemistry
Online Access:http://link.springer.com/article/10.1186/s12885-019-6182-3

Internet

http://link.springer.com/article/10.1186/s12885-019-6182-3

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