Loss of p53 epigenetically modulates epithelial to mesenchymal transition in colorectal cancer

Loss of p53 epigenetically modulates epithelial to mesenchymal transition in colorectal cancer

Epithelial to Mesenchymal transition (EMT) drives cancer metastasis and is governed by genetic and epigenetic alterations at multiple levels of regulation. It is well established that loss/mutation of p53 confers oncogenic function to cancer cells and promotes metastasis. Though transcription factor...

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Bibliographic Details
Main Authors: Shreya Sharma, Harsha Rani, Yeshwanth Mahesh, Mohit Kumar Jolly, Jagannath Dixit, Vijayalakshmi Mahadevan
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Translational Oncology
Subjects:
Cancer epigenetics
Epithelial to mesenchymal transition
colorectal cancer
p53
SATB1
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323002346

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http://www.sciencedirect.com/science/article/pii/S1936523323002346

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