Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors.

Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors.

Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible for this narrow species tropism are not well defined. Virus cell entry involves human scavenger receptor class B type I (SR-BI), CD81, claudin-1 and occludin. Among these, at least CD81 and occludin a...

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Bibliographic Details
Main Authors: Julia Bitzegeio, Dorothea Bankwitz, Kathrin Hueging, Sibylle Haid, Christiane Brohm, Mirjam B Zeisel, Eva Herrmann, Marcus Iken, Michael Ott, Thomas F Baumert, Thomas Pietschmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2895659?pdf=render

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http://europepmc.org/articles/PMC2895659?pdf=render

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