Clinical Implications of Monogenic Versus Polygenic Hypercholesterolemia: Long‐Term Response to Treatment, Coronary Atherosclerosis Burden, and Cardiovascular Events

Clinical Implications of Monogenic Versus Polygenic Hypercholesterolemia: Long‐Term Response to Treatment, Coronary Atherosclerosis Burden, and Cardiovascular Events

Background Familial hypercholesterolemia (FH) may arise from deleterious monogenic variants in FH‐causing genes as well as from a polygenic cause. We evaluated the relationships between monogenic FH and polygenic hypercholesterolemia in influencing the long‐term response to therapy and the risk of a...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Laura D’Erasmo, Ilenia Minicocci, Alessia Di Costanzo, Giovanni Pigna, Daniela Commodari, Fabrizio Ceci, Anna Montali, Francesca Brancato, Ilaria Stanca, Antonio Nicolucci, Andrea Ascione, Nicola Galea, Iacopo Carbone, Marco Francone, Marianna Maranghi, Marcello Arca
Formaat:	Artikel
Taal:	English
Gepubliceerd in:	Wiley 2021-05-01
Reeks:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Onderwerpen:	atherosclerosis cardiovascular disease genetics hypercholesterolemia therapy
Online toegang:	https://www.ahajournals.org/doi/10.1161/JAHA.120.018932

Gelijkaardige items

Higher Responsiveness to Rosuvastatin in Polygenic versus Monogenic Hypercholesterolemia: A Propensity Score Analysis
door: Agnieszka Mickiewicz, et al.
Gepubliceerd in: (2020-05-01)

Family and polygenic hypercholesterolemia: similarities and differencies by long-term follow-up
door: B M Lipovetskiy, et al.
Gepubliceerd in: (2009-03-01)

A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin
door: Luis G. Leal, et al.
Gepubliceerd in: (2020-06-01)

Polygenic risk score for hypercholesterolemia in a Brazilian familial hypercholesterolemia cohort
door: Isabella Ramos Lima, et al.
Gepubliceerd in: (2022-08-01)

Efficacy of Evolocumab in Monogenic vs Polygenic Hypercholesterolemia
door: Timothy Lee, BSc, et al.
Gepubliceerd in: (2019-05-01)

Genetics of Hypercholesterolemia: Comparison Between Familial Hypercholesterolemia and Hypercholesterolemia Nonrelated to LDL Receptor
door: Estíbaliz Jarauta, et al.
Gepubliceerd in: (2020-12-01)

Real‐World Effectiveness of PCSK9 Inhibitors in Reducing LDL‐C in Patients With Familial Hypercholesterolemia in Italy: A Retrospective Cohort Study Based on the AIFA Monitoring Registries
door: Marcello Arca, et al.
Gepubliceerd in: (2023-11-01)

Clinical Significance of Screening for Familial Hypercholesterolemia in Patients with Hypercholesterolemia
door: LI Yuan, MA Hongyang, LI Biao, YUE Anna, SHAO Yaqing, SUN Kangyun
Gepubliceerd in: (2024-12-01)

LIPOPROTEIN (a) LEVELS IN MONOGENIC VERSUS POLYGENIC HYPERCHOLESTEROLEMIA
door: A. Jain, et al.
Gepubliceerd in: (2021-09-01)

Twelve Variants Polygenic Score for Low‐Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations
door: Elena Olmastroni, et al.
Gepubliceerd in: (2022-04-01)

New Treatments on the Horizon for Familial Hypercholesterolemia
door: Khalid Al-Rasadi, et al.
Gepubliceerd in: (2017-11-01)

Familial Hypercholesterolemia in Cardiac Rehabilitation: a new field of interest
door: Marco Ambrosetti, et al.
Gepubliceerd in: (2015-08-01)

The panorama of familial hypercholesterolemia in Latin America: a systematic review[S]
door: Roopa Mehta, et al.
Gepubliceerd in: (2016-12-01)

The burden of severe hypercholesterolemia and familial hypercholesterolemia in a population-based setting in the US
door: Seyedmohammad Saadatagah, et al.
Gepubliceerd in: (2022-12-01)

Genetic Determinants of Plasma Low-Density Lipoprotein Cholesterol Levels: Monogenicity, Polygenicity, and “Missing” Heritability
door: Jesús Maria Martín-Campos
Gepubliceerd in: (2021-11-01)

SITOSTEROLEMIA – RARE CAUSE OF HYPERCHOLESTEROLEMIA IN CHILD
door: Antoneta Dacia Petroaie
Gepubliceerd in: (2019-02-01)

Familial homozygous hypercholesterolemia with arcus cornea and xanthomas: A rare but serious entity
door: Amal Chamli, et al.
Gepubliceerd in: (2023-03-01)

Role of lipoprotein apheresis in the management of familial hypercholesterolemia
door: Shamanna Seshadri Iyengar, et al.
Gepubliceerd in: (2021-01-01)

School-based universal screening for hypercholesterolemia in children
door: Chang-Hsien Yu, et al.
Gepubliceerd in: (2022-07-01)

The prevalence of familial hypercholesterolemia in teenagers from Timișoara
door: Andreea Dumitrescu¹,²,, et al.
Gepubliceerd in: (2016-12-01)

Effects of <i>Lippia citriodora</i> Leaf Extract on Lipid and Oxidative Blood Profile of Volunteers with Hypercholesterolemia: A Preliminary Study
door: Antonella Angiolillo, et al.
Gepubliceerd in: (2021-03-01)

Familial hypercholesterolemia revealed by multiple xanthomas
door: Nassiba Elouarradi, et al.
Gepubliceerd in: (2018-05-01)

A case of familial hypercholesterolemia
door: Augusto Zaninelli
Gepubliceerd in: (2008-06-01)

Monacolin K in the treatment of hypercholesterolemia - chance or threat?
door: Katarzyna Krotowska
Gepubliceerd in: (2024-12-01)

Immune Modulatory Effects of Hypercholesterolemia: Can Atorvastatin Convert the Detrimental Effect of Hypercholesterolemia on the Immune System?
door: Zeinab Emruzi, et al.
Gepubliceerd in: (2019-10-01)

Hypertension and Hypercholesterolemia: is it Time for Anti-«Lipitensive» Therapy?
door: Z. D. Kobalava, et al.
Gepubliceerd in: (2020-11-01)

Relationship between hypercholesterolemia and osteoarthritis (preliminary results)
door: Elena A. Taskina, et al.
Gepubliceerd in: (2024-06-01)

Early Atherosclerosis in Children in Familial Hypercholesterolemia : A 2 Case Report
door: Narumon Densupsoontorn, et al.
Gepubliceerd in: (2020-08-01)

Benefit–risk assessment of pitavastatin for the treatment of hypercholesterolemia in older patients
door: Chamberlin KW, et al.
Gepubliceerd in: (2015-04-01)

Lipoprotein(a) Genotype Influences the Clinical Diagnosis of Familial Hypercholesterolemia
door: Elena Olmastroni, et al.
Gepubliceerd in: (2023-05-01)

Safety and Effectiveness of Low‐Density Lipoprotein Cholesterol–Lowering Therapy With Evolocumab for Familial Hypercholesterolemia/Hypercholesterolemia in Japan: A Real‐World, Postmarketing, Single‐Arm Study
door: Koutaro Yokote, et al.
Gepubliceerd in: (2024-11-01)

Amaranthus viridis L. as alternative treatment for hypercholesterolemia and atherosclerosis
door: Salvamani, Shamala
Gepubliceerd in: (2016)

Clinical case of myocardial infarction with unspecified familial hypercholesterolemia
door: Natalya G. Lozhkina, et al.
Gepubliceerd in: (2022-01-01)

Doppler study of cerebral arteries in hypercholesterolemia
door: Ghabili K
Gepubliceerd in: (2011-03-01)

Genetic Testing for Familial Hypercholesterolemia in a Pediatric Group: A Romanian Showcase
door: Andreea Teodora Constantin, et al.
Gepubliceerd in: (2023-06-01)

Unraveling the genetic background of individuals with a clinical familial hypercholesterolemia phenotype
door: Ana Margarida Medeiros, et al.
Gepubliceerd in: (2024-02-01)

Familial hypercholesterolemia: The skin speaks
door: Johns T Johnson, et al.
Gepubliceerd in: (2020-01-01)

The Prevalence and Genetic Spectrum of Familial Hypercholesterolemia in Qatar Based on Whole Genome Sequencing of 14,000 Subjects
door: Ilhame Diboun, et al.
Gepubliceerd in: (2022-07-01)

Patient experiences align with the familial hypercholesterolemia global call to action
door: Laney K. Jones, et al.
Gepubliceerd in: (2022-06-01)

Scientific Disagreement and Evidential Pluralism: Lessons from the Studies on Hypercholesterolemia
door: Veli-Pekka Parkkinen, et al.
Gepubliceerd in: (2018-05-01)