Successful anti-tumor effects with two novel bifunctional chemotherapeutic compounds that combine a LAT1 substrate with cytotoxic moieties in aggressive T-cell lymphomas

Successful anti-tumor effects with two novel bifunctional chemotherapeutic compounds that combine a LAT1 substrate with cytotoxic moieties in aggressive T-cell lymphomas

T-cell lymphomas are aggressive neoplasms characterized by poor responses to current chemotherapeutic agents. Expression of the l-type amino acid transporter 1 (LAT 1, SLC7A5) allows for the expansion of healthy T-cell counterparts, and upregulation of LAT1 has been reported in precursor T-cell acut...

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Bibliographic Details
Main Authors: Carlos Murga-Zamalloa, Shaun Webb, John Reneau, Alejandro Zevallos, Pierina Danos-Diaz, Vanessa Perez-Silos, Mirna Rodriguez, Guangyao Gao, Wolf-Nicolas Fischer, Bernd Jandeleit, Ryan Wilcox
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Leukemia Research Reports
Subjects:
SLC7A5
LAT1
T-cell lymphomas
QBS10072S
QBS10096S
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048923000389

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http://www.sciencedirect.com/science/article/pii/S2213048923000389

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