Loading Dose of Ceftazidime Needs to Be Increased in Critically Ill Patients: A Retrospective Study to Evaluate Recommended Loading Dose with Pharmacokinetic Modelling

Loading Dose of Ceftazidime Needs to Be Increased in Critically Ill Patients: A Retrospective Study to Evaluate Recommended Loading Dose with Pharmacokinetic Modelling

To rapidly achieve ceftazidime target concentrations, a 2 g loading dose (LD) is recommended before continuous infusion, but its adequacy in critically ill patients, given their unique pharmacokinetics, needs investigation. This study included patients from six ICUs in Saint-Etienne and Paris, Franc...

Full description

Bibliographic Details
Main Authors: Manon Launay, Edouard Ollier, Benjamin Kably, Félicien Le Louedec, Guillaume Thiery, Julien Lanoiselée, Sophie Perinel-Ragey
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Antibiotics
Subjects:
ceftazidime
loading dose
critically ill patients
pharmacokinetics
volume of distribution
model-based simulations
Online Access:https://www.mdpi.com/2079-6382/13/8/756

Internet

https://www.mdpi.com/2079-6382/13/8/756

Similar Items