Lower beta cell yield from donor pancreases after controlled circulatory death prevented by shortening acirculatory warm ischemia time and by using IGL-1 cold preservation solution.

Lower beta cell yield from donor pancreases after controlled circulatory death prevented by shortening acirculatory warm ischemia time and by using IGL-1 cold preservation solution.

Organs from donors after controlled circulatory death (DCD III) exhibit a higher risk for graft dysfunction due to an initial period of warm ischemia. This procurement condition can also affect the yield of beta cells in islet isolates from donor pancreases, and hence their use for transplantation....

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Bibliographic Details
Main Authors: Diedert L De Paep, Freya Van Hulle, Zhidong Ling, Marian Vanhoeij, Jacques Pirenne, Bart Keymeulen, Daniel Pipeleers, Daniel Jacobs-Tulleneers-Thevissen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0251055&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0251055&type=printable

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