Perinatal outcome of fetuses with echogenic intracardiac focus
Objective: Echogenic intracardiacs focus (EIF), a microcalcification of the papillary muscles in either or both ventricles of the fetal heart, is one of the more common ultrasonographic soft markers of trisomy 21. This study aimed to determine the relationship of EIF with trisomies in the presence o...
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IMR Press
2020-06-01
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Series: | Clinical and Experimental Obstetrics & Gynecology |
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Online Access: | https://www.imrpress.com/journal/CEOG/47/3/10.31083/j.ceog.2020.03.5121 |
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author | M. Özsürmeli M. Sucu E. Arslan S. Büyükkurt |
author_facet | M. Özsürmeli M. Sucu E. Arslan S. Büyükkurt |
author_sort | M. Özsürmeli |
collection | DOAJ |
description | Objective: Echogenic intracardiacs focus (EIF), a microcalcification of the papillary muscles in either or both ventricles of the fetal heart, is one of the more common ultrasonographic soft markers of trisomy 21. This study aimed to determine the relationship of EIF with trisomies in the presence of various ultrasonographic findings. Materials and Methods: A retrospective study of second-trimester obstetric sonograms (18-24 weeks) was conducted at a tertiary care center over a two-year period. The patients were divided into three groups: isolated EIF (group 1), EIF with at least one soft marker (group 2), and EIF with structural anomalies (group 3). All the groups were divided into subgroups on the basis of a screening test (maternal age ≥ 35, positive combined-triple-quadruple tests). The incidence of chromosome anomalies was evaluated. Results: The authors examined 8,300 patients during the study period and found 170 fetuses with isolated EIF (group 1), 26 fetuses with EIF and soft markers (group 2), and 37 fetuses with EIF and structural anomalies (group 3). Thirteen (8%) patients underwent fetal karyotyping in group 1, 10 (38%) in group 2, and 22 (60%) in group 3. The rate of the invasive test was higher in fetuses exhibiting EIF accompanied by at least one of the soft markers. No trisomy was detected in group 1 or 2. Conclusion: The risk of aneuploidy did not increase in either isolated EIF or in cases with other soft markers but only in cases with structural anomalies. |
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issn | 0390-6663 |
language | English |
last_indexed | 2024-04-12T17:19:54Z |
publishDate | 2020-06-01 |
publisher | IMR Press |
record_format | Article |
series | Clinical and Experimental Obstetrics & Gynecology |
spelling | doaj.art-89a03461a795462e9f243ca0cf9508fd2022-12-22T03:23:31ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-06-0147337237510.31083/j.ceog.2020.03.5121S0390-6663(20)00268-7Perinatal outcome of fetuses with echogenic intracardiac focusM. Özsürmeli0M. Sucu1E. Arslan2S. Büyükkurt3Derince Research and Education Hospital, Department of Obstetrics and Gynecology, Kocaeli, TurkeyUniversity of Çukurova, School of Medicine, Department of Obstetrics and Gynecology, Perinatology Unit, Adana, TurkeyUniversity of Çukurova, School of Medicine, Department of Obstetrics and Gynecology, Perinatology Unit, Adana, TurkeyUniversity of Çukurova, School of Medicine, Department of Obstetrics and Gynecology, Perinatology Unit, Adana, TurkeyObjective: Echogenic intracardiacs focus (EIF), a microcalcification of the papillary muscles in either or both ventricles of the fetal heart, is one of the more common ultrasonographic soft markers of trisomy 21. This study aimed to determine the relationship of EIF with trisomies in the presence of various ultrasonographic findings. Materials and Methods: A retrospective study of second-trimester obstetric sonograms (18-24 weeks) was conducted at a tertiary care center over a two-year period. The patients were divided into three groups: isolated EIF (group 1), EIF with at least one soft marker (group 2), and EIF with structural anomalies (group 3). All the groups were divided into subgroups on the basis of a screening test (maternal age ≥ 35, positive combined-triple-quadruple tests). The incidence of chromosome anomalies was evaluated. Results: The authors examined 8,300 patients during the study period and found 170 fetuses with isolated EIF (group 1), 26 fetuses with EIF and soft markers (group 2), and 37 fetuses with EIF and structural anomalies (group 3). Thirteen (8%) patients underwent fetal karyotyping in group 1, 10 (38%) in group 2, and 22 (60%) in group 3. The rate of the invasive test was higher in fetuses exhibiting EIF accompanied by at least one of the soft markers. No trisomy was detected in group 1 or 2. Conclusion: The risk of aneuploidy did not increase in either isolated EIF or in cases with other soft markers but only in cases with structural anomalies.https://www.imrpress.com/journal/CEOG/47/3/10.31083/j.ceog.2020.03.5121diagnosisprenatal ultrasonographytrisomiesabnormalitycongenital |
spellingShingle | M. Özsürmeli M. Sucu E. Arslan S. Büyükkurt Perinatal outcome of fetuses with echogenic intracardiac focus Clinical and Experimental Obstetrics & Gynecology diagnosis prenatal ultrasonography trisomies abnormality congenital |
title | Perinatal outcome of fetuses with echogenic intracardiac focus |
title_full | Perinatal outcome of fetuses with echogenic intracardiac focus |
title_fullStr | Perinatal outcome of fetuses with echogenic intracardiac focus |
title_full_unstemmed | Perinatal outcome of fetuses with echogenic intracardiac focus |
title_short | Perinatal outcome of fetuses with echogenic intracardiac focus |
title_sort | perinatal outcome of fetuses with echogenic intracardiac focus |
topic | diagnosis prenatal ultrasonography trisomies abnormality congenital |
url | https://www.imrpress.com/journal/CEOG/47/3/10.31083/j.ceog.2020.03.5121 |
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