Perinatal outcome of fetuses with echogenic intracardiac focus

Objective: Echogenic intracardiacs focus (EIF), a microcalcification of the papillary muscles in either or both ventricles of the fetal heart, is one of the more common ultrasonographic soft markers of trisomy 21. This study aimed to determine the relationship of EIF with trisomies in the presence o...

Full description

Bibliographic Details
Main Authors: M. Özsürmeli, M. Sucu, E. Arslan, S. Büyükkurt
Format: Article
Language:English
Published: IMR Press 2020-06-01
Series:Clinical and Experimental Obstetrics & Gynecology
Subjects:
Online Access:https://www.imrpress.com/journal/CEOG/47/3/10.31083/j.ceog.2020.03.5121
_version_ 1811255181091799040
author M. Özsürmeli
M. Sucu
E. Arslan
S. Büyükkurt
author_facet M. Özsürmeli
M. Sucu
E. Arslan
S. Büyükkurt
author_sort M. Özsürmeli
collection DOAJ
description Objective: Echogenic intracardiacs focus (EIF), a microcalcification of the papillary muscles in either or both ventricles of the fetal heart, is one of the more common ultrasonographic soft markers of trisomy 21. This study aimed to determine the relationship of EIF with trisomies in the presence of various ultrasonographic findings. Materials and Methods: A retrospective study of second-trimester obstetric sonograms (18-24 weeks) was conducted at a tertiary care center over a two-year period. The patients were divided into three groups: isolated EIF (group 1), EIF with at least one soft marker (group 2), and EIF with structural anomalies (group 3). All the groups were divided into subgroups on the basis of a screening test (maternal age ≥ 35, positive combined-triple-quadruple tests). The incidence of chromosome anomalies was evaluated. Results: The authors examined 8,300 patients during the study period and found 170 fetuses with isolated EIF (group 1), 26 fetuses with EIF and soft markers (group 2), and 37 fetuses with EIF and structural anomalies (group 3). Thirteen (8%) patients underwent fetal karyotyping in group 1, 10 (38%) in group 2, and 22 (60%) in group 3. The rate of the invasive test was higher in fetuses exhibiting EIF accompanied by at least one of the soft markers. No trisomy was detected in group 1 or 2. Conclusion: The risk of aneuploidy did not increase in either isolated EIF or in cases with other soft markers but only in cases with structural anomalies.
first_indexed 2024-04-12T17:19:54Z
format Article
id doaj.art-89a03461a795462e9f243ca0cf9508fd
institution Directory Open Access Journal
issn 0390-6663
language English
last_indexed 2024-04-12T17:19:54Z
publishDate 2020-06-01
publisher IMR Press
record_format Article
series Clinical and Experimental Obstetrics & Gynecology
spelling doaj.art-89a03461a795462e9f243ca0cf9508fd2022-12-22T03:23:31ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-06-0147337237510.31083/j.ceog.2020.03.5121S0390-6663(20)00268-7Perinatal outcome of fetuses with echogenic intracardiac focusM. Özsürmeli0M. Sucu1E. Arslan2S. Büyükkurt3Derince Research and Education Hospital, Department of Obstetrics and Gynecology, Kocaeli, TurkeyUniversity of Çukurova, School of Medicine, Department of Obstetrics and Gynecology, Perinatology Unit, Adana, TurkeyUniversity of Çukurova, School of Medicine, Department of Obstetrics and Gynecology, Perinatology Unit, Adana, TurkeyUniversity of Çukurova, School of Medicine, Department of Obstetrics and Gynecology, Perinatology Unit, Adana, TurkeyObjective: Echogenic intracardiacs focus (EIF), a microcalcification of the papillary muscles in either or both ventricles of the fetal heart, is one of the more common ultrasonographic soft markers of trisomy 21. This study aimed to determine the relationship of EIF with trisomies in the presence of various ultrasonographic findings. Materials and Methods: A retrospective study of second-trimester obstetric sonograms (18-24 weeks) was conducted at a tertiary care center over a two-year period. The patients were divided into three groups: isolated EIF (group 1), EIF with at least one soft marker (group 2), and EIF with structural anomalies (group 3). All the groups were divided into subgroups on the basis of a screening test (maternal age ≥ 35, positive combined-triple-quadruple tests). The incidence of chromosome anomalies was evaluated. Results: The authors examined 8,300 patients during the study period and found 170 fetuses with isolated EIF (group 1), 26 fetuses with EIF and soft markers (group 2), and 37 fetuses with EIF and structural anomalies (group 3). Thirteen (8%) patients underwent fetal karyotyping in group 1, 10 (38%) in group 2, and 22 (60%) in group 3. The rate of the invasive test was higher in fetuses exhibiting EIF accompanied by at least one of the soft markers. No trisomy was detected in group 1 or 2. Conclusion: The risk of aneuploidy did not increase in either isolated EIF or in cases with other soft markers but only in cases with structural anomalies.https://www.imrpress.com/journal/CEOG/47/3/10.31083/j.ceog.2020.03.5121diagnosisprenatal ultrasonographytrisomiesabnormalitycongenital
spellingShingle M. Özsürmeli
M. Sucu
E. Arslan
S. Büyükkurt
Perinatal outcome of fetuses with echogenic intracardiac focus
Clinical and Experimental Obstetrics & Gynecology
diagnosis
prenatal ultrasonography
trisomies
abnormality
congenital
title Perinatal outcome of fetuses with echogenic intracardiac focus
title_full Perinatal outcome of fetuses with echogenic intracardiac focus
title_fullStr Perinatal outcome of fetuses with echogenic intracardiac focus
title_full_unstemmed Perinatal outcome of fetuses with echogenic intracardiac focus
title_short Perinatal outcome of fetuses with echogenic intracardiac focus
title_sort perinatal outcome of fetuses with echogenic intracardiac focus
topic diagnosis
prenatal ultrasonography
trisomies
abnormality
congenital
url https://www.imrpress.com/journal/CEOG/47/3/10.31083/j.ceog.2020.03.5121
work_keys_str_mv AT mozsurmeli perinataloutcomeoffetuseswithechogenicintracardiacfocus
AT msucu perinataloutcomeoffetuseswithechogenicintracardiacfocus
AT earslan perinataloutcomeoffetuseswithechogenicintracardiacfocus
AT sbuyukkurt perinataloutcomeoffetuseswithechogenicintracardiacfocus