Mechanical stretch promotes apoptosis and impedes ciliogenesis of primary human airway basal stem cells

Mechanical stretch promotes apoptosis and impedes ciliogenesis of primary human airway basal stem cells

Abstract Background Airway basal stem cells (ABSCs) have self-renewal and differentiation abilities. Although an abnormal mechanical environment related to chronic airway disease (CAD) can cause ABSC dysfunction, it remains unclear how mechanical stretch regulates the behavior and structure of ABSCs...

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Bibliographic Details
Main Authors: Li-Qin Lin, Hai-Kang Zeng, Yu-Long Luo, Di-Fei Chen, Xiao-Qian Ma, Huan-Jie Chen, Xin-Yu Song, Hong-Kai Wu, Shi-Yue Li
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Respiratory Research
Subjects:
Airway basal stem cells
Mechanical stretch
Ciliogenesis
Online Access:https://doi.org/10.1186/s12931-023-02528-w

Internet

https://doi.org/10.1186/s12931-023-02528-w

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