Exploration of broadly neutralizing antibody fragments produced in bacteria for the control of HIV

Exploration of broadly neutralizing antibody fragments produced in bacteria for the control of HIV

While broadly neutralizing antibodies (bnAbs) are a promising preventative and therapeutic tool for HIV infection, production is difficult and expensive. Production of antibody-like fragments in bacterial cytoplasm provides a cheaper alternative. This work explored the transplantation of the complem...

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Bibliographic Details
Main Authors: Sarah B. Lloyd, Keith P. Niven, Ben R. Kiefel, David C. Montefiori, Arnold Reynaldi, Miles P. Davenport, Stephen J. Kent, Wendy R. Winnall
Format: Article
Language:English
Published: Taylor & Francis Group 2017-11-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
10e8
broadly neutralizing antibodies
diabodies
e. coli expression
human immunodeficiency virus
pgt121
single-chain variable fragment antibodies
tandem-scfv
Online Access:http://dx.doi.org/10.1080/21645515.2017.1368935

Internet

http://dx.doi.org/10.1080/21645515.2017.1368935

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