Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium

Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium

Major Histocompatibility Complex (MHC)-I and -II genes are upregulated in intestinal epithelial cells (IECs) during active inflammatory bowel diseases (IBD), but little is known about how IBD-relevant pro-inflammatory signals and IBD drugs can regulate their expression. We have previously shown that...

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Bibliographic Details
Main Authors: Shreya Gopalakrishnan, Marianne Doré Hansen, Helene Kolstad Skovdahl, Ingrid Aass Roseth, Atle van Beelen Granlund, Ann Elisabet Østvik, Ingunn Bakke, Arne Kristian Sandvik, Torunn Bruland
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
intestinal epithelium
organoids
tumor necrosis factor (TNF)
polyinosinic:polycytidylic acid Poly(I:C)
antigen presentation
major histocompatibility class II
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.882277/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.882277/full

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