Endothelial Progenitor Cells Promote Osteosarcoma Progression and Invasiveness via AKT/PI3K Signaling

Endothelial Progenitor Cells Promote Osteosarcoma Progression and Invasiveness via AKT/PI3K Signaling

Background: Osteosarcoma (OS) mortality is attributed to lung metastases. Endothelial progenitor cells (EPCs) mediate the angiogenic switch in several cancers. The spatial proximity between EPCs and OS in the bone led to the hypothesis that EPCs-osteosarcoma interactions may possibly promote OS prog...

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Bibliographic Details
Main Authors: Ofri Doppelt-Flikshtain, Amin Younis, Tal Tamari, Ofir Ginesin, Talia Shentzer-Kutiel, David Nikomarov, Gil Bar-Sela, Benjamin R. Coyac, Yehuda G. Assaraf, Hadar Zigdon-Giladi
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
endothelial progenitor cells
osteosarcoma
metastasis
Online Access:https://www.mdpi.com/2072-6694/15/6/1818

Internet

https://www.mdpi.com/2072-6694/15/6/1818

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