Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors

Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors

Elicitation of broadly neutralizing antibodies remains a long-standing goal of HIV vaccine research. Although such antibodies can arise during HIV-1 infection, gaps in our knowledge of their germline, pre-immune precursor forms, as well as on their interaction with viral Env, limit our ability to el...

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Bibliographic Details
Main Authors: Christina Yacoob, Marie Pancera, Vladimir Vigdorovich, Brian G. Oliver, Jolene A. Glenn, Junli Feng, D. Noah Sather, Andrew T. McGuire, Leonidas Stamatatos
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Cell Reports
Subjects:
HIV
VRC01
broadly neutralizing antibodies
human alleles
CDRH3
germline
human antibodies
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716314036

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http://www.sciencedirect.com/science/article/pii/S2211124716314036

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