Prior AICAR induces elevated glucose uptake concomitant with greater γ3-AMPK activation and reduced membrane cholesterol in skeletal muscle from 26-month-old rats

Prior AICAR induces elevated glucose uptake concomitant with greater γ3-AMPK activation and reduced membrane cholesterol in skeletal muscle from 26-month-old rats

Attenuated skeletal muscle glucose uptake (GU) has been observed with advancing age. It is important to elucidate the mechanisms linked to interventions that oppose this detrimental outcome. Earlier research using young rodents and (or) cultured myocytes reported that treatment with 5-aminoimidazole...

Full description

Bibliographic Details
Main Authors: Haiyan Wang, Amy Zheng, Edward B. Arias, Gregory D. Cartee
Format: Article
Language:English
Published: Canadian Science Publishing 2022-01-01
Series:FACETS
Subjects:
insulin sensitivity
glucose transport
AMP-activated protein kinase
aging
cholesterol
skeletal muscle
Online Access:https://facetsjournal.com/doi/10.1139/facets-2021-0166

Internet

https://facetsjournal.com/doi/10.1139/facets-2021-0166

Similar Items