A Chromatin-Focused siRNA Screen for Regulators of p53-Dependent Transcription

A Chromatin-Focused siRNA Screen for Regulators of p53-Dependent Transcription

The protein product of the Homo sapiens TP53 gene is a transcription factor (p53) that regulates the expression of genes critical for the response to DNA damage and tumor suppression, including genes involved in cell cycle arrest, apoptosis, DNA repair, metabolism, and a number of other tumorigenesi...

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Bibliographic Details
Main Authors: Morgan A. Sammons, Jiajun Zhu, Shelley L. Berger
Format: Article
Language:English
Published: Oxford University Press 2016-08-01
Series:G3: Genes, Genomes, Genetics
Subjects:
chromatin
p53
siRNA screen
epigenetics
H. sapiens
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.116.031534

Internet

http://g3journal.org/lookup/doi/10.1534/g3.116.031534

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