Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination
Bordetella pertussis (Bp), the causative agent of pertussis, continues to circulate and it’s not well understood how (sub)clinical infections shape immune memory to Bp and vaccination. Here, using a mutant Bp strain lacking antigens of the acellular pertussis vaccine, the authors show how prior expo...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35165-w |
| _version_ | 1797985561435176960 |
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| author | Evi van Schuppen Janeri Fröberg Prashanna Balaji Venkatasubramanian Pauline Versteegen Hans de Graaf Jana Holubová Joshua Gillard Pieter G. M. van Gageldonk Irma Joosten Ronald de Groot Peter Šebo Guy A. M. Berbers Robert C. Read Martijn A. Huynen Marien I. de Jonge Dimitri A. Diavatopoulos |
| author_facet | Evi van Schuppen Janeri Fröberg Prashanna Balaji Venkatasubramanian Pauline Versteegen Hans de Graaf Jana Holubová Joshua Gillard Pieter G. M. van Gageldonk Irma Joosten Ronald de Groot Peter Šebo Guy A. M. Berbers Robert C. Read Martijn A. Huynen Marien I. de Jonge Dimitri A. Diavatopoulos |
| author_sort | Evi van Schuppen |
| collection | DOAJ |
| description | Bordetella pertussis (Bp), the causative agent of pertussis, continues to circulate and it’s not well understood how (sub)clinical infections shape immune memory to Bp and vaccination. Here, using a mutant Bp strain lacking antigens of the acellular pertussis vaccine, the authors show how prior exposure to Bp shapes the mucosal antibody response to booster vaccination. |
| first_indexed | 2024-04-11T07:20:00Z |
| format | Article |
| id | doaj.art-89b65445de2a46a88e026c42b7c1a8cc |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T07:20:00Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-89b65445de2a46a88e026c42b7c1a8cc2022-12-22T04:37:48ZengNature PortfolioNature Communications2041-17232022-12-0113111110.1038/s41467-022-35165-wPrior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccinationEvi van Schuppen0Janeri Fröberg1Prashanna Balaji Venkatasubramanian2Pauline Versteegen3Hans de Graaf4Jana Holubová5Joshua Gillard6Pieter G. M. van Gageldonk7Irma Joosten8Ronald de Groot9Peter Šebo10Guy A. M. Berbers11Robert C. Read12Martijn A. Huynen13Marien I. de Jonge14Dimitri A. Diavatopoulos15Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, RadboudumcLaboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, RadboudumcCenter for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, RadboudumcNational Institute for Public Health and the Environment, Centre for Infectious Disease ControlFaculty of Medicine and Institute for Life Sciences, University of Southampton, Academic Unit of Clinical Experimental Sciences, National Institute of Health Research (NIHR) Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital SouthamptonInstitute of Microbiology of the Czech Academy of SciencesLaboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, RadboudumcNational Institute for Public Health and the Environment, Centre for Infectious Disease ControlLaboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, RadboudumcLaboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, RadboudumcInstitute of Microbiology of the Czech Academy of SciencesNational Institute for Public Health and the Environment, Centre for Infectious Disease ControlFaculty of Medicine and Institute for Life Sciences, University of Southampton, Academic Unit of Clinical Experimental Sciences, National Institute of Health Research (NIHR) Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital SouthamptonCenter for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, RadboudumcLaboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, RadboudumcLaboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, RadboudumcBordetella pertussis (Bp), the causative agent of pertussis, continues to circulate and it’s not well understood how (sub)clinical infections shape immune memory to Bp and vaccination. Here, using a mutant Bp strain lacking antigens of the acellular pertussis vaccine, the authors show how prior exposure to Bp shapes the mucosal antibody response to booster vaccination.https://doi.org/10.1038/s41467-022-35165-w |
| spellingShingle | Evi van Schuppen Janeri Fröberg Prashanna Balaji Venkatasubramanian Pauline Versteegen Hans de Graaf Jana Holubová Joshua Gillard Pieter G. M. van Gageldonk Irma Joosten Ronald de Groot Peter Šebo Guy A. M. Berbers Robert C. Read Martijn A. Huynen Marien I. de Jonge Dimitri A. Diavatopoulos Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination Nature Communications |
| title | Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination |
| title_full | Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination |
| title_fullStr | Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination |
| title_full_unstemmed | Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination |
| title_short | Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination |
| title_sort | prior exposure to b pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination |
| url | https://doi.org/10.1038/s41467-022-35165-w |
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