Alteration of gastric microbiota and transcriptome in a rat with gastric intestinal metaplasia induced by deoxycholic acid

Alteration of gastric microbiota and transcriptome in a rat with gastric intestinal metaplasia induced by deoxycholic acid

ObjectiveBile reflux plays a key role in the development of gastric intestinal metaplasia (GIM), an independent risk factor of gastric cancer. Here, we aimed to explore the biological mechanism of GIM induced by bile reflux in a rat model.MethodsRats were treated with 2% sodium salicylate and allowe...

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Bibliographic Details
Main Authors: Zijing Xu, Ling Xiao, Shuaishuai Wang, Yuqin Cheng, Jianping Wu, Yufen Meng, Kaifan Bao, Junfeng Zhang, Chun Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Microbiology
Subjects:
gastric intestinal metaplasia
microbiota
bile acids
transcriptome
correlation analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1160821/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1160821/full

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